Research

Medical research.

Work in neonatal and pediatric infectious diseases, antimicrobial stewardship, congenital CMV, respiratory viral illness, and acute lung injury.

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Current research

Projects in lung injury and pediatric infectious diseases.

Acute lung injury

Macrophage mTORC1 signaling in a mouse model

Through the NIH-funded STRIVE T35 program at The Ohio State University, I am studying macrophage mTORC1 signaling in an endotoxin-induced mouse model of acute lung injury with Joshua Englert, MD. This preclinical work examines how macrophage signaling shapes the inflammatory response in lung injury, with relevance to the biology of acute respiratory distress syndrome.

Workflow for preparing rapamycin-loaded liposomes using thin-film formation and bath sonication
Preparation workflow for rapamycin-loaded liposomes. Experimental schematic provided by Zachery S. Lewald and the Englert Lab.

Pediatric infectious diseases

Congenital CMV and neonatal outcomes

At Nationwide Children’s Hospital, my current projects include work on false-positive congenital cytomegalovirus screening tests—accepted for publication in the Pediatric Infectious Disease Journal—and a study comparing small for gestational age with intrauterine growth restriction in infants with congenital CMV. The projects focus on diagnostic interpretation and clinically meaningful differences within neonatal infection.

Labeled structure of a cytomegalovirus virion showing envelope proteins, tegument, capsid, and double-stranded DNA genome
Structural organization of the CMV virion and its double-stranded DNA genome. Figure 1 from Liu Y, et al., Human cytomegalovirus: pathogenesis, prevention, and treatment (2024).

Recognition & training

Research support and early training.

STRIVE T35 · Bethesda, Maryland

A visit to the National Institutes of Health.

As part of the 12-week STRIVE T35 research program, our cohort visited the NIH Clinical Center in Bethesda. We toured NIH facilities, spoke with researchers, and attended rounds in the Clinical Center—a chance to see how questions developed at the bench connect with clinical investigation and public service.

The STRIVE T35 cohort at the NIH Clinical Center in Bethesda, Maryland
STRIVE T35 cohort at the NIH Clinical Center.
Members of the STRIVE T35 cohort during their NIH visit
Cohort members during the NIH visit.

IVY Network

Collaborative publications

Nonauthor collaborator through the Investigating Respiratory Viruses in the Acutely Ill Network. Each record links directly to PubMed.

PubMed

RSV Vaccine Effectiveness Against Hospitalization Among US Adults Aged 60 Years or Older During 2 Seasons

Surie D, Self WH, Yuengling KA, et al. JAMA. 2025;334(16):1442–1451.

DOI: 10.1001/jama.2025.15896 · PMID: 40884491

View on PubMed

PubMed

Long-Term Illness in Adults Hospitalized for Respiratory Syncytial Virus Disease, United States, February 2022–September 2023

Leis AM, Womack KN, Maxcy C, et al. Emerging Infectious Diseases. 2025;31(Suppl).

DOI: 10.3201/eid3114.241982 · PMID: 41570181

View on PubMed

PubMed

Benefit of Early Oseltamivir Therapy for Adults Hospitalized With Influenza A: An Observational Study

Lewis NM, Harker EJ, Grant LB, et al. Clinical Infectious Diseases. 2025;81(1):190–197.

DOI: 10.1093/cid/ciae584 · PMID: 39607747

View on PubMed

PubMed

Effectiveness of Updated 2023–2024 COVID-19 Vaccination Against XBB and BA.2.86/JN.1 Lineage Hospitalization

Ma KC, Surie D, Lauring AS, et al. Clinical Infectious Diseases.

DOI: 10.1093/cid/ciae405 · PMID: 39107255

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PubMed

Severity of Respiratory Syncytial Virus vs COVID-19 and Influenza Among Hospitalized US Adults

Surie D, Yuengling KA, DeCuir J, et al. JAMA Network Open. 2024;7(4):e244954.

DOI: 10.1001/jamanetworkopen.2024.4954 · PMID: 38573635

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PubMed

Vaccine Effectiveness Against Influenza A–Associated Hospitalization, Organ Failure, and Death: United States, 2022–2023

Lewis NM, Zhu Y, Peltan ID, et al. Clinical Infectious Diseases. 2023.

DOI: 10.1093/cid/ciad677 · PMID: 38051664

View on PubMed

Current roles

Research & clinical service

Conference work

Posters & presentations

Poster sessions, invited talks, and collaborative presentations in neonatal and pediatric infectious diseases.

Zach Lewald standing beside his neonatal pneumonia research poster
Neonatal pneumonia research.
Zach Lewald and Pablo Sánchez standing in front of a congenital CMV poster at PAS 2023
Congenital CMV at PAS 2023.
Research team standing in front of the neonatal pneumonia antibiotic therapy poster
With neonatal pneumonia collaborators.
Zach Lewald and Pablo Sánchez at a pediatric infectious diseases research conference
Pediatric infectious diseases conference.

Poster

Small but Not the Same: SGA vs. IUGR in Congenital CMV Infection

Nationwide Children’s Hospital Neonatal/Fetal Conference · Columbus, Ohio · April 13, 2026

Poster

Small but Not the Same: SGA vs. IUGR in Congenital CMV Infection

Pediatric Academic Societies Meeting · Boston, Massachusetts · March 26, 2026

Poster collaborator

CMV Infection in Very-Low-Birth-Weight Infants: Congenital vs. Postnatal Infections

Pediatric Academic Societies Meeting · Boston, Massachusetts · March 26, 2026

Poster

Small but Not the Same: SGA vs. IUGR in Congenital CMV Infection

St. Jude/PIDS Pediatric Infectious Diseases Research Conference · Memphis, Tennessee · March 4, 2026

Poster

“False-Positive” Cytomegalovirus Screening Tests in Neonates: One Test Is Not Enough!

Nationwide Children’s Hospital Research Retreat · Columbus, Ohio · November 18, 2025

Invited oral presentation

“False-Positive” Cytomegalovirus Screening Tests in Neonates: One Test Is Not Enough!

Medical Student Grand Rounds · The Ohio State University College of Medicine · November 4, 2025

Poster

Late-Onset Hearing Loss and Antiviral Therapy for Congenital Cytomegalovirus Infection

St. Jude/PIDS Pediatric Infectious Diseases Research Conference · Memphis, Tennessee · March 7, 2024

Poster

“False-Positive” Cytomegalovirus Screening Tests in Neonates

IDWeek · Boston, Massachusetts · October 13, 2023

Poster collaborator

Neurodevelopmental Outcomes in Congenital CMV Infection with CNS Involvement

Pediatric Academic Societies Meeting · Washington, DC · April 30, 2023

Poster collaborator

Late-Onset Hearing Loss and Antiviral Therapy for Congenital Cytomegalovirus Infection

Pediatric Academic Societies Meeting · Washington, DC · April 30, 2023

Poster

Antibiotic Therapy for Pneumonia in the NICU: Is 5 Days Enough?

St. Jude/PIDS Pediatric Infectious Diseases Research Conference · Memphis, Tennessee · March 2, 2023

Poster

Antibiotic Therapy for Pneumonia in the Neonatal Intensive Care Unit

Midwest Society for Pediatric Research · Chicago, Illinois · September 29–30, 2022

Poster

Antibiotic Therapy for Pneumonia in the NICU: Is 5 Days Enough?

Pediatric Academic Societies Meeting · April 25, 2022

Research page last updated August 2026.